We read with interest, recently published article in this journal titled “Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study,” the authors describe increased mortality at 42 days in patients transfused with fresh frozen plasma (FFP) for acute variceal hemorrhage.¹ Within the FFP-transfused group, variceal bleeding was the leading cause of mortality, and the authors report that most deaths were related to worsening portal hypertension. They further describe that patients transfused additional units of FFP had significantly higher odds ratio of failure to control bleeding at 5 days and hospital length of stay (LOS) >7 days, with a 26% increased risk of failure to control bleeding with each additional unit of FFP. The authors concluded that there is no benefit of FFP transfusion but rather a potential harm in cirrhotics with acute variceal bleed. Authors did not provide any data on fibrinogen level in these patients.

中文翻译：

---

肝硬化患者低纤维蛋白原血症发生率观察

我们饶有兴趣地阅读了本期刊最近发表的题为“急性静脉曲张出血的新鲜冰冻血浆输注：多中心队列研究的结果”的文章，作者描述了输注新鲜冰冻血浆 (FFP) 的急性急性静脉曲张患者在 42 天内的死亡率增加静脉曲张出血。¹在 FFP 输注组中，静脉曲张出血是死亡的主要原因，作者报告说，大多数死亡与门静脉高压症恶化有关。他们进一步描述了输注额外单位 FFP 的患者在 5 天时无法控制出血和住院时间 (LOS) > 7 天的比值比显着更高，每增加一个单位，无法控制出血的风险增加 26% FFP 的。作者得出的结论是，FFP 输血没有好处，反而对伴有急性静脉曲张出血的肝硬化有潜在危害。作者没有提供有关这些患者纤维蛋白原水平的任何数据。