Lithium chloride (LiCl) is an emetic drug that has been used to create animal models of anticipatory nausea and conditioned place aversion. In this study we examined escape behaviours from a context in which rats experienced the aversive effects of LiCl treatments. The experiment had two phases: acquisition of context conditioning, which consisted of pairing a distinct context with the pharmacological effects of a moderate dose of the toxin LiCl, and extinction of context conditioning, which consisted of placement in the distinct context in a drug free state. During context conditioning, 16 adult male Long-Evans rats were injected intraperitoneally with 96 mg/kg lithium chloride (LiCl; n = 8) or 0.9% saline (NaCl; n = 8) and placed individually in an automated locomotor activity apparatus for 30 min every other day for 4 days. During the extinction phase, rats were placed in the apparatus for 30 min every other day without injections during a 4 day extinction phase. A significant Drug x Trial interaction was found for the time spent in vertical position in the open field apparatus during trials 1–3 of the extinction phase. The LiCl treated rats exhibited significantly increased rearing behavior, relative to the control rats, indicative of conditioned aversion. The results of this study suggest that escape behavior (vertical activity) occurs in rats experiencing the aversive conditioned effects of LiCl in a distinct context. In the context of current theoretical accounts, the LiCl-conditioned increase in apparent escape behaviors can be considered a reflection of anticipatory nausea.

氯化锂 (LiCl) 是一种催吐药物，已被用于创建预期性恶心和条件性位置厌恶的动物模型。在这项研究中，我们检查了大鼠经历 LiCl 治疗厌恶影响的背景下的逃逸行为。该实验有两个阶段：获得上下文条件，包括将不同的上下文与中等剂量的 LiCl 毒素的药理作用配对，以及上下文条件的消失，包括以无药物状态放置在不同的上下文中. 在情境条件反射期间，16 只成年雄性 Long-Evans 大鼠腹膜内注射 96 mg/kg 氯化锂（LiCl；n  = 8）或 0.9% 盐水（NaCl；n = 8) 并在 4 天内每隔一天单独放置在自动运动活动装置中 30 分钟。在灭绝阶段，大鼠每隔一天被放置在装置中 30 分钟，在 4 天的灭绝阶段不注射。在灭绝阶段的试验 1-3 期间，在开放场设备中垂直位置花费的时间发现了显着的药物 x 试验相互作用。与对照大鼠相比，LiCl 处理的大鼠表现出显着增加的饲养行为，表明条件厌恶。这项研究的结果表明，逃避行为（垂直活动）发生在经历 LiCl 厌恶条件影响的大鼠身上。在当前理论账户的背景下，