ABSTRACT

Purpose

We conducted a systematic search to estimate DR prevalence in different age and gender groups, and to evaluate the determinants of heterogeneity in its prevalence.

Methods

A systematic and comprehensive search from inception to August 10, 2020, was done in international databases, including Scopus, PubMed, Web of Science, Embase, and other data sources without any restriction to find cross-sectional studies related to the prevalence of DR.

Results

Of 6399 studies, 90 articles with a sample size of 563460 individuals and 204189 diabetic patients were analyzed. The estimated pooled prevalence of DR in the diabetic population in general; in female and in male was 28.41% (95% CI: 25.98 to 30.84); 25.93% (95% CI: 23.54 to 28.31) and 28.95% (95% CI: 26.57 to 31.32); respectively and the prevalence of DR showed no inter-gender difference. The heterogeneity of the pooled prevalence according to I² was 99% (p < .001). According to the meta-regression results, the variables of WHO region (Coefficient of AMRO vs SEARO: 15.56; p: 0.002), age (Coefficient of above 60 years vs below 40 year: 18.67; p: 0.001), type of DR (Coefficient: 19.01; p < .001), and publication year (Coefficient: -0.60; p: 0.001) had a significant correlation with heterogeneity.

Conclusion

One third of diabetic patients suffered from DR, mostly NPDR. DR increased markedly after the age of 60 years, which could be due to the longer duration of diabetes. Age, WHO region, type of DR, and publication year affected the heterogeneity in the prevalence of DR.

中文翻译：

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糖尿病视网膜病变的全球和区域患病率；全面的系统评价和荟萃分析

摘要

目的

我们进行了系统搜索以估计不同年龄和性别组的 DR 患病率，并评估其患病率异质性的决定因素。

方法

从开始到 2020 年 8 月 10 日，系统全面地检索了国际数据库，包括 Scopus、PubMed、Web of Science、Embase 和其他数据源，没有任何限制，以找到与 DR 患病率相关的横断面研究。

结果

在 6399 项研究中，分析了 90 篇文章，样本量为 563460 人和 204189 名糖尿病患者。一般糖尿病人群中 DR 的估计汇总患病率；女性和男性为 28.41%（95% CI：25.98 至 30.84）；25.93%（95% CI：23.54 至 28.31）和 28.95%（95% CI：26.57 至 31.32）；分别，DR的患病率没有性别差异。根据 I ²的汇总患病率的异质性为 99% ( p < .001)。根据元回归结果，WHO 地区变量（AMRO 与 SEARO 的系数：15.56；p：0.002）、年龄（60 岁以上与 40 岁以下的系数：18.67；p：0.001）、DR 类型（系数：19.01；p< .001）和出版年份（系数：-0.60；p：0.001）与异质性显着相关。

结论

三分之一的糖尿病患者患有 DR，主要是 NPDR。60岁以后DR显着增加，这可能是由于糖尿病病程更长。年龄、WHO 地区、DR 类型和发表年份影响 DR 患病率的异质性。