Background. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. Results. 34.1% of the patients were euthyroid. Length of hospitalization (), rate of oxygen demand (), and intensive care unit (ICU) admission () were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease.

中文翻译：

---

COVID-19 中甲状腺激素变化与炎症状态和预后的关系

背景。除了对肺部和免疫系统的影响外，COVID-19 感染还可能具有多器官影响。最近，研究发现 COVID-19 病例的甲状腺功能异常被解释为甲状腺功能正常疾病综合征 (ESS) 或破坏性甲状腺炎。因此，在本研究中，我们旨在评估 COVID-19 患者的甲状腺功能状态和甲状腺自身免疫。材料和方法。纳入 205 名患者。从病历中收集入院时的病史和实验室参数。测定血清促甲状腺激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、甲状腺过氧化物酶抗体、甲状腺球蛋白抗体，根据甲状腺功能状态对患者进行分类。结果. 34.1% 的患者甲状腺功能正常。住院时间（),需氧量 ()和重症监护病房 (ICU) 入院 ()较低，并且没有一个甲状腺功能正常的患者死亡。108 名 (52.6%) 患者被归类为 ESS，57 名被归类为轻度，51 名被归类为中度。中度 ESS 患者的炎症参数较高。在聚类分析中，FT3 中位数较低（中位数 = 2.34 ng/L；IQR = 0.86）、FT4 中位数较高（中位数 = 1.04 ng/dL；IQR = 0.33）和中位数较低的高风险组TSH 值（中位数 = 0.62 mIU/L；IQR = 0.59）包括 9 名死亡患者中的 8 名和入住 ICU 的 31 名患者中的 25 名。讨论. 甲状腺功能正常的患者住院时间、需氧量、ICU入院时间和死亡率较低。此外，没有一个甲状腺功能正常的患者死亡。总之，在 COVID-19 感染期间评估甲状腺功能检查可能会提供有关疾病预后的信息。