当前位置: X-MOL 学术Respir. Physiol. Neurobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impact of obesity and ovariectomy on respiratory function in female mice
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-08-17 , DOI: 10.1016/j.resp.2021.103775
Ana C R Lopes 1 , Bruno Zavan 2 , Yuri J C Corrêa 1 , Tânia M Vieira 1 , Liza J Severs 3 , Luiz M Oliveira 3 , Roseli Soncini 1
Affiliation  

Obesity and the corresponding variations in female sex hormones are associated with severe lung disease. We determined the potential effects of obesity and sex hormones in female mice by investigating changes in lung structure and respiratory function in an obesity model induced by postnatal overnutrition. Obese female mice exhibited pronounced weight gain, abdominal fat accumulation and collagen type I deposition in the airways. However, neither elastic tissue nor estrogen receptors-α/-β were affected in obese female mice after ovariectomy or sham-operated mice. Bronchoconstriction in response to methacholine challenge in obese sham-operated mice was higher than in the obese group after ovariectomy. Our results suggest that the coexistence of obesity and ovariectomy impacted on respiratory system and airway resistance (attenuates bronchoconstriction after methacholine), on collagen I deposition and on airway estrogen β-receptors of mice.



中文翻译:

肥胖和卵巢切除对雌性小鼠呼吸功能的影响

肥胖和女性性激素的相应变化与严重的肺部疾病有关。我们通过研究产后营养过剩引起的肥胖模型中肺结构和呼吸功能的变化,确定了肥胖和性激素对雌性小鼠的潜在影响。肥胖的雌性小鼠表现出明显的体重增加、腹部脂肪堆积和气道中 I 型胶原蛋白的沉积。然而,卵巢切除术后或假手术小鼠的肥胖雌性小鼠的弹性组织和雌激素受体-α/-β均未受到影响。在卵巢切除术后,肥胖假手术小鼠对乙酰甲胆碱挑战的支气管收缩高于肥胖组。

更新日期:2021-08-19
down
wechat
bug