Phenolic compounds with anti-inflammatory effects from Knema furfuracea,Results in Chemistry

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Phenolic compounds with anti-inflammatory effects from Knema furfuracea
Results in Chemistry ( IF 2.5 ) Pub Date : 2021-08-17 , DOI: 10.1016/j.rechem.2021.100175
Chao-Fan Wang ₁ , Fang Kuang ₁ , Wen-Jiang Wang ₁ , Lei Luo ₁ , Qiu-Xia Li ₁ , Ying Liu ₁ , Rui Zhan ₁

Affiliation

Knema furfuracea is a tropical evergreen plant, which belongs to Myristicaceae family. Phytochemical investigation on the twigs and leaves of K. furfuracea led to the isolation of 11 phenolic compounds, including a new flavonoid knemavane A (1). These compounds belong to flavonoids, lignans, and anarardic acids. Biological evaluation of the inhibitory activities of compounds 1–11 against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages showed that compounds 1 (IC₅₀ = 13.79 μM), 2 (IC₅₀ = 9.28 μM), and 6 (IC₅₀ = 15.14 μM) were active.

中文翻译：

来自 Knema furfuracea 的具有抗炎作用的酚类化合物

Knema furfuracea是一种热带常绿植物，属于肉豆蔻科。对K. furfuracea树枝和叶子的植物化学研究导致分离出 11 种酚类化合物，包括一种新的类黄酮 knemavane A ( 1 )。这些化合物属于类黄酮、木脂素和花生四烯酸。化合物的抑制活性的生物学评价1 - 11对一氧化氮（NO）产生的LPS活化的巨噬细胞的RAW264.7表明，化合物1（IC ₅₀ = 13.79μM），2（IC ₅₀ = 9.28μM），和6（ IC ₅₀ = 15.14 μM) 是有活性的。

更新日期：2021-08-21

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