Impairment of type I interferon (IFN-I) immunity has been reported in critically ill COVID-19 patients. This defect can be explained in a subset of patients by the presence of circulating autoantibodies (auto-Abs) against IFN-I. We set out to improve the detection and the quantification of IFN-I auto-Abs in a cohort of critically ill COVID-19 patients, in order to better evaluate the prevalence of these Abs as the pandemic progresses, and how they correlate with the clinical course of the disease.

中文翻译：

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针对 I 型干扰素的抗体：检测和与 COVID-19 患者严重临床结果的关联

据报道，重症 COVID-19 患者 I 型干扰素 (IFN-I) 免疫力受损。这种缺陷可以通过存在针对 IFN-I 的循环自身抗体 (auto-Abs) 来解释部分患者。我们着手改进对一组危重 COVID-19 患者的 IFN-I 自身抗体的检测和量化，以便更好地评估这些抗体随着大流行的进展的流行情况，以及它们与临床的相关性。病程。