ABSTRACT

Pancreatic islet transplantation to restore insulin production in Type 1 Diabetes Mellitus patients is commonly performed by infusion of islets into the hepatic portal system. However, the risk of portal vein thrombosis or elevation of portal pressure after transplantation introduces challenges to this procedure. Thus, alternative sites have been investigated, among which the omentum represents an ideal candidate. The surgical site is easily accessible, and the tissue is highly vascularized with a large surface area for metabolic exchange. Furthermore, the ability of the omentum to host large volumes of islets represents an intriguing if not ideal site for encapsulated islet transplantation. Research on the safety and efficacy of the omentum as a transplant site focuses on the utilization of biologic scaffolds or encapsulation of islets in a biocompatible semi-permeable membrane. Currently, more clinical trials are required to better characterize the safety and efficacy of islet transplantation into the omentum.

 抽象的

用于恢复 1 型糖尿病患者胰岛素产生的胰岛移植通常是通过将胰岛输注到肝门系统中来进行的。然而，移植后门静脉血栓形成或门静脉压力升高的风险给该手术带来了挑战。因此，已经研究了替代部位，其中大网膜是理想的候选部位。手术部位易于接近，组织血管化程度高，具有较大的表面积用于代谢交换。此外，大网膜容纳大量胰岛的能力即使不是封装胰岛移植的理想位点，也是一个有趣的位点。关于大网膜作为移植部位的安全性和有效性的研究重点是利用生物支架或将胰岛封装在生物相容性半透膜中。目前，需要更多的临床试验来更好地表征胰岛移植到大网膜的安全性和有效性。