ABSTRACT

Spermatogenesis process plays a major role in male fertility. Quercetin, a flavonoid, is found in daily food or traditional Chinese medicine, which has a significant effect on treating inflammatory diseases. Several studies have shown that quercetin can improve male spermatogenesis. However, the intrinsic mechanism has not been systematically investigated. The network pharmacology approaches were utilized to investigate the mechanisms of quercetin against spermatogenesis impairment (SI). 78 potential therapeutic targets of quercetin against SI were identified. The enrichment analysis showed that the mechanism of quercetin on SI is closely related to its anti-inflammatory pharmacological effects. It is indicated that quercetin could be used for treating SI through inflammation-related targets or pathways including NF-κB, MAPK, JAK-STAT and Toll-like receptor signaling pathways.

摘要

精子发生过程在男性生育能力中起主要作用。槲皮素是一种黄酮类化合物，存在于日常食物或中药中，对治疗炎症性疾病有显着效果。多项研究表明，槲皮素可以改善男性精子发生。然而，尚未系统地研究其内在机制。利用网络药理学方法研究槲皮素对抗精子发生障碍 (SI) 的机制。确定了 78 个槲皮素针对 SI 的潜在治疗靶点。富集分析表明，槲皮素对SI的作用机制与其抗炎药理作用密切相关。表明槲皮素可通过炎症相关靶点或通路（包括 NF-κB、MAPK、