Various Co-containing hydrotalcites (LDHs) with different cations (Fe, Al, Ga and MgAl) were prepared, characterized, and investigated in the aerobic oxidation of ethylbenzene to acetophenone. The results indicated that the coupled cations have significant effect on the catalytic performance, and Co₂Fe-LDH exhibited the highest catalytic activity. Synergistic effect between Co and Fe species has been obviously observed, and Fe species was able to significantly assist the catalytic oxidation over Co-containing LDHs. The high catalytic performance was proposed to be related to the high Co²⁺ content and its increased intrinsic activity, and electron transfer between Co and Fe species in the reaction. Under the optimized conditions, a 97.6 % conversion of ethylbenzene with a high 94.9 % selectivity to acetophenone could be obtained. According to the analysis of structure-activity relationship, hammett experiments and a series of control experiments, the possible reaction pathways for the aerobic oxidation of ethylbenzene over Co₂Fe-LDH have been proposed.

制备、表征和研究了具有不同阳离子（Fe、Al、Ga 和 MgAl）的各种含 Co 水滑石（LDH）在乙苯有氧氧化成苯乙酮的过程中。结果表明，偶联阳离子对催化性能有显着影响，Co ₂ Fe-LDH表现出最高的催化活性。已经明显观察到 Co 和 Fe 物种之间的协同作用，并且 Fe 物种能够显着协助含 Co LDH 的催化氧化。高催化性能被认为与高 Co ^{2+ 相关}含量及其增加的本征活性，以及​​反应中 Co 和 Fe 物种之间的电子转移。在优化条件下，乙苯转化率为 97.6%，苯乙酮选择性为 94.9%。通过构效关系分析、hammett实验和一系列对照实验，提出了乙苯在Co ₂ Fe-LDH上有氧氧化的可能反应途径。