RNA-binding proteins (RBPs) play crucial roles in the post-transcriptional regulation of mRNA during numerous physiological and pathological processes, including tumor genesis and development. However, the role of RNA-binding motif protein 43 (RBM43) in esophageal squamous cell carcinoma (ESCC) has not been reported so far. The current study was the first to evaluate RBM43 protein expression by immunohistochemistry (IHC) in an independent cohort of 207 patients with ESCC, to explore its potential prognostic value and clinical relevance in ESCC. The results indicated that RBM43 protein levels were significantly elevated in ESCC tissues and increased RBM43 expression was associated with age and N categories. In addition, ESCC patients with high expression of RBM43 had shorter overall survival (OS) and disease‐free survival (DFS) than those with low RBM43 expression. Furthermore, when survival analyses were conducted at different clinical stages, overexpression of RBM43 was significantly correlated with shortened survival in patients with ESCC at early stages (TNM stage I–II and N0 stage). Cox regression analysis further proved that high RBM43 expression was an independent predictor of poor prognosis in ESCC patients. In conclusion, increased expression of RBM43 is correlated with malignant attributes to ESCC and predicts unfavorable prognosis, suggesting an effective prognostic biomarker and potential therapeutic target for ESCC.

RNA 结合蛋白 (RBP) 在包括肿瘤发生和发展在内的众多生理和病理过程中，在 mRNA 的转录后调控中发挥着至关重要的作用。然而，迄今为止尚未报道 RNA 结合基序蛋白 43 (RBM43) 在食管鳞状细胞癌 (ESCC) 中的作用。本研究首次通过免疫组织化学 (IHC) 在 207 名 ESCC 患者的独立队列中评估 RBM43 蛋白表达，以探索其在 ESCC 中的潜在预后价值和临床相关性。结果表明，ESCC组织中RBM43蛋白水平显着升高，RBM43表达增加与年龄和N类别相关。此外，RBM43高表达的ESCC患者的总生存期（OS）和无病生存期（DFS）比RBM43低表达的患者短。此外，当在不同临床阶段进行生存分析时，RBM43 的过表达与早期 ESCC 患者（TNM I-II 期和 N0 期）的生存期缩短显着相关。Cox回归分析进一步证明RBM43高表达是ESCC患者预后不良的独立预测因子。总之，RBM43 表达增加与 ESCC 的恶性属性相关，并预测不良预后，提示 ESCC 的有效预后生物标志物和潜在治疗靶点。RBM43 的过表达与早期 ESCC 患者（TNM I-II 期和 N0 期）的生存期缩短显着相关。Cox回归分析进一步证明RBM43高表达是ESCC患者预后不良的独立预测因子。总之，RBM43 表达增加与 ESCC 的恶性属性相关，并预测不良预后，提示 ESCC 的有效预后生物标志物和潜在治疗靶点。RBM43 的过表达与早期 ESCC 患者（TNM I-II 期和 N0 期）的生存期缩短显着相关。Cox回归分析进一步证明RBM43高表达是ESCC患者预后不良的独立预测因子。总之，RBM43 表达增加与 ESCC 的恶性属性相关，并预测不良预后，提示 ESCC 的有效预后生物标志物和潜在治疗靶点。