In this issue of JEM, Guo et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202350) examine the importance of tumor-derived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which excitingly can be targeted by BMP inhibitors.

中文翻译：

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复发性髓母细胞瘤的 SHHecret 靶标：星形胶质细胞

在本期JEM中，Guo 等人。(2021. J. Exp. Med. https://doi.org/10.1084/jem.20202350) 检查肿瘤源性星形胶质细胞在 SHH 髓母细胞瘤复发中的重要性。他们表明，肿瘤细胞通过骨形态发生蛋白和 Sox9 转分化为肿瘤源性星形胶质细胞，令人兴奋的是，Sox9 可以成为 BMP 抑制剂的靶标。