Psoriatic arthritis (PsA) affects about 0.8% of the general population. Together with psoriasis is termed psoriatic disease. Comorbidities play an important role in the clinical expression and treatment of psoriatic disease. Ageing adds another level of complexity, partly because age directly accrues increasing risk of comorbidities, but also due to its complex interactions with several factors such as depression and social determinants. Ageing seems to have a "paradoxical association" with cardiovascular comorbidities for which the relative risk is more pronounced in younger patients with psoriatic disease and also to affect treatment decisions and response in patients with psoriatic disease. Finally, there is convincing evidence that there are clinical, genetic and histopathological differences between young- and late- onset PsA and psoriasis. Herein, we review the effect of age in patients with psoriatic disease, with a focus on PsA, highlighting the need to consider this feature in routine clinical practice as well as in the research domain.

中文翻译：

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年龄对银屑病关节炎有影响吗？叙述性评论。

银屑病关节炎 (PsA) 影响大约 0.8% 的普通人群。与银屑病一起被称为银屑病。合并症在银屑病的临床表现和治疗中起着重要作用。老龄化增加了另一个层次的复杂性，部分原因是年龄直接增加了合并症的风险，但也由于它与抑郁症和社会决定因素等多种因素的复杂相互作用。衰老似乎与心血管合并症存在“矛盾关联”，心血管合并症的相对风险在年轻银屑病患者中更为明显，并且还会影响银屑病患者的治疗决策和反应。最后，有令人信服的证据表明，临床上，年轻和晚发 PsA 和银屑病之间的遗传和组织病理学差异。在此，我们回顾了年龄对银屑病患者的影响，重点是 PsA，强调需要在常规临床实践和研究领域考虑这一特征。