In this narrative review, we summarise the evidence for and against the glycaemic legacy effect from the long-term follow-up of major diabetes trials and observational cohort studies. We provide a summary of the pathophysiological basis for the legacy effect and discuss some translational research. Results from trials of early diabetes and observational cohort studies suggest that a long-term effect of early glycaemic control exists; however, long-term follow-up from trials in participants with established diabetes is not supportive. Additionally, findings for the legacy effect are more conclusive for microvascular complications than macrovascular events. Overall, these results suggest that the glycaemic legacy effect is a long-term benefit (or risk) conferred to individuals in the early stages of diabetes and which is muted over time as individuals’ vasculature changes and they develop complications from diabetes.

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中文翻译：

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糖尿病的遗留效应：有长期的好处吗？

在这篇叙述性综述中，我们总结了主要糖尿病试验和观察性队列研究的长期随访中支持和反对血糖遗留效应的证据。我们总结了遗留效应的病理生理学基础，并讨论了一些转化研究。早期糖尿病试验和观察性队列研究的结果表明，早期血糖控制存在长期影响；然而，对已确诊糖尿病的参与者进行的试验的长期随访并不支持。此外，与大血管事件相比，微血管并发症的遗留效应更具有决定性。全面的，

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