Abstract

Context

Garden cress (GC), fenugreek (FG), and black seed (BS) are traditional herbal medicine for managing hypertension.

Objective

The effects of the three herbs on the pharmacodynamics of metoprolol tartrate (MT) in hypertensive rats were investigated.

Materials and methods

Wistar rats were divided in five groups (n = 6). Group I served as normal control group and Group II (hypertensive control group) had rats treated orally with N-nitro L-arginine methyl ester (L-NAME, 40 mg/kg/day) only. Groups III, IV, and V rats were orally treated with L-NAME (40 mg/kg/day) + GC (300 mg/kg, once daily), L-NAME (40 mg/kg/day) + FG (300 mg/kg, once daily) and L-NAME (40 mg/kg/day) + BS (300 mg/kg, once daily), respectively, for 2 weeks, and on the 14th day, blood pressure and heart rate were recorded using a tail-cuff blood pressure-measuring system. On the 16th day, a single dose of MT (10 mg/kg) was orally administered, and the rats’ blood pressure and heart rate were recorded.

Results

GC, FG, and BS decreased systolic blood pressure (SBP) by 8.7%, 8.5%, and 8.7%, respectively, in hypertensive rats. A greater decrease in SBP by 14.5%, 14.8%, and 16.1% was observed when hypertensive rats were treated with L-NAME + GC + MT, L-NAME + FG + MT, and L-NAME + BS + MT, respectively. Similarly, hypertensive rats treated with the combination of herbs and MT had significantly lower diastolic blood pressure (DBP) than those treated with herbs alone and those treated with L-NAME alone.

Conclusions

The combination of investigated herbs and MT had a beneficial effect on hypertension. However, the concurrent administration of drugs, particularly those predominantly cleared through CYP450 2D6-catalyzed metabolism, with the three investigated herbs should be considered with caution.

中文翻译：

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水芹、胡芦巴和黑籽对美托洛尔药效学的影响：高血压大鼠的草药-药物相互作用研究

摘要

语境

水芹 (GC)、胡芦巴 (FG) 和黑种子 (BS) 是治疗高血压的传统草药。

客观的

研究了三种药材对酒石酸美托洛尔 (MT) 对高血压大鼠药效学的影响。

材料和方法

Wistar 大鼠分为五组 ( n  = 6)。第一组为正常对照组，第二组（高血压对照组）只给大鼠口服N-硝基L-精氨酸甲酯（L- NAME，40mg/kg/天）。III、IV 和 V 组大鼠口服L- NAME（40 mg/kg/天）+GC（300 mg/kg，每天一次）、L- NAME（40 mg/kg/天）+FG（300 mg/kg，每天一次）和L-NAME (40 mg/kg/day) + BS (300 mg/kg, 每天一次)，分别持续 2 周，在第 14 天，使用尾袖血压测量仪记录血压和心率系统。第16天，口服单剂量MT（10 mg/kg），记录大鼠血压和心率。

结果

在高血压大鼠中，GC、FG 和 BS 分别降低了 8.7%、8.5% 和 8.7% 的收缩压 (SBP)。当高血压大鼠分别用L -NAME + GC + MT、L -NAME + FG + MT 和L -NAME + BS + MT治疗时，SBP 下降幅度更大，分别为 14.5%、14.8% 和 16.1% 。同样，用草药和 MT 联合治疗的高血压大鼠的舒张压 (DBP) 显着低于单独用草药治疗的大鼠和单独用L- NAME 治疗的大鼠。

结论

研究的草药和 MT 的组合对高血压有有益的作用。然而，应谨慎考虑同时施用药物，特别是那些主要通过 CYP450 2D6 催化代谢清除的药物，与三种研究的草药。