Sleep-disordered breathing in Australian children with Prader-Willi syndrome following initiation of growth hormone therapy,Journal of Paediatrics and Child Health

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Sleep-disordered breathing in Australian children with Prader-Willi syndrome following initiation of growth hormone therapy
Journal of Paediatrics and Child Health ( IF 1.6 ) Pub Date : 2021-08-16 , DOI: 10.1111/jpc.15691
Daan Caudri _{1,

2} , Gillian M Nixon _{3,

4} , Aleisha Nielsen ₅ , Linda Mai ₆ , Claire R Hafekost ₁ , Nitin Kapur _{7,

8} , Chris Seton _{9,

10} , Andrew Tai _{11,

12} , Greg Blecher ₁₃ , Geoff Ambler _{14,

15} , Philip B Bergman _{4,

16} , Komal A Vora _{17,

18} , Patricia Crock ₁₇ , Charles F Verge _{19,

20} , Elaine Tham ₂₁ , Yassmin Musthaffa _{8,

22,

23} , Antony R Lafferty _{24,

25} , Peter Jacoby ₁ , Andrew C Wilson _{1,

5,

6,

26} , Jenny Downs _{1,

26} , Catherine S Choong _{1,

27}

Affiliation

Telethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Department of Paediatric Pulmonology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Victoria, Australia.
Department of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Respiratory and Sleep Medicine, Perth Children's Hospital, Perth, Western Australia, Australia.
Faculty of Medicine and Health Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia.
School of Clinical Medicine, University of Queensland, Brisbane, Queensland, Australia.
Department of Sleep Medicine, Children's Hospital Westmead, Sydney, New South Wales, Australia.
Woolcock Institute of Medical Research, Sydney University, Sydney, New South Wales, Australia.
Respiratory and Sleep Department, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Department of Sleep Medicine, Sydney Children's Hospital, Randwick, New South Wales, Australia.
The Sydney Children's Hospitals Network, Westmead, New South Wales, Australia.
Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia.
Department of Paediatric Endocrinology & Diabetes, Monash Children's Hospital, Melbourne, Victoria, Australia.
Department of Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, New South Wales, Australia.
School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Department of Endocrinology, Sydney Children's Hospital, Randwick, New South Wales, Australia.
School of Women's and Children's Health, The University of New South Wales, Sydney, New South Wales, Australia.
Endocrinology and Diabetes Department, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Department of Endocrinology and Diabetes, Queensland Children's Hospital, Brisbane, Queensland, Australia.
Department of Paediatrics, Logan Hospital, Brisbane, Queensland, Australia.
Department of Endocrinology and Diabetes, Canberra Hospital, Garran, Australian Capital Territory, Australia.
Medical School, Australian National University, Canberra, Australian Capital Territory, Australia.
School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia.
Department of Endocrinology, Perth Children's Hospital, Perth, Western Australia, Australia.

In children with Prader-Willi syndrome (PWS), growth hormone (GH) improves height and body composition; however, may be associated with worsening sleep-disordered breathing (SDB). Some studies have reported less SDB after GH initiation, but follow-up with polysomnography is still advised in most clinical guidelines.

中文翻译：

开始生长激素治疗后，患有 Prader-Willi 综合征的澳大利亚儿童出现睡眠呼吸障碍

在患有 Prader-Willi 综合征 (PWS) 的儿童中，生长激素 (GH) 可以改善身高和身体成分；然而，可能与睡眠呼吸障碍 (SDB) 恶化有关。一些研究报告 GH 开始后 SDB 较少，但大多数临床指南仍建议使用多导睡眠图进行随访。

更新日期：2021-08-16

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