Wound healing is impaired with advanced age and certain chronic conditions, such as diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and radiation, can cause unintended tissue damage and impair wound healing. Available wound care treatments are not always effective, as some wounds fail to heal or recur after treatment. Hence, a more thorough understanding of the pathophysiology of chronic, nonhealing wounds may offer new ideas for the development of effective wound care treatments. Cancers are sometimes referred to as wounds that never heal, sharing mechanisms similar to wound healing. We describe in this review how cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to chronic wounds versus cancer.

高龄和某些慢性疾病（如糖尿病和肥胖）会影响伤口愈合。此外，常见的癌症治疗，包括化学疗法和放射疗法，可能会导致意外的组织损伤并损害伤口愈合。可用的伤口护理治疗并不总是有效的，因为有些伤口在治疗后无法愈合或复发。因此，更彻底地了解慢性、不愈合伤口的病理生理学可能为开发有效的伤口护理治疗提供新思路。癌症有时被称为永远不会愈合的伤口，其共享机制类似于伤口愈合。我们在这篇综述中描述了细胞衰老和衰老相关分泌表型 (SASP) 如何导致慢性伤口与癌症。