ABSTRACT

Purpose

To compare peripapillary choroidal vascularity index (CVI) parameters in pseudoexfoliation glaucoma (PEG), pseudoexfoliation (PEX) syndrome, and healthy controls.

Methods

A total of 240 eyes of 240 patients were included in this cross-sectional prospective study, and the three groups consisted of (i) 80 eyes of 80 patients with PEG, (ii) 80 eyes of 80 patients with PEX syndrome, and (iii) 80 healthy control eyes. Peripapillary enhanced depth imaging optical coherence tomography images were binarized via standard protocols with the ImageJ software. CVI was analyzed in all sectors of the peripapillary region.

Results

Peripapillary CVI was found to be significantly lower in the PEG group (61.6 ± 2.32) compared with the PEX group (64.7 ± 3.15) and the control group (67.5 ± 2.44) (p < .001), and patients with PEX also had significantly lower values compared to controls (p < .001). Peripapillary CVI values were significantly lower in the temporal, nasal, superotemporal, superonasal, inferotemporal and inferonasal sectors of the PEG group compared to both the PEX group and controls (p < .001). Peripapillary CVI was also found to be lower in all sectors in the PEX group compared to controls (p < .001). Global peripapillary choroidal thickness was significantly thinner in the PEG group than the PEX and control groups (133.37 ± 39.16, 154.36 ± 33.28 and 157.82 ± 36.77 μm, respectively, p < .001).

Conclusions

In the current study, it was shown that the presence of PEX caused a decrease in CVI value and this decrease was highest in patients with PEG. CVI may be a useful parameter to show vascular dysfunction in PEG and PEX syndrome.

中文翻译：

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假性剥脱性青光眼、假性剥脱综合征和健康对照组脉络膜血管指数的比较

摘要

目的

比较假性剥脱性青光眼 (PEG)、假性剥脱 (PEX) 综合征和健康对照组的视乳头周围脉络膜血管指数 (CVI) 参数。

方法

这项横断面前瞻性研究共纳入 240 名患者的 240 只眼，三组包括 (i) 80 名 PEG 患者的 80 只眼，(ii) 80 名 PEX 综合征患者的 80 只眼，和 (iii) ) 80 只健康对照眼。使用 ImageJ 软件通过标准协议对周围增强深度成像光学相干断层扫描图像进行二值化。CVI 在视乳头周围区域的所有部分进行了分析。

结果

与 PEX 组 (64.7 ± 3.15) 和对照组 (67.5 ± 2.44) 相比，PEG 组 (61.6 ± 2.32) 的视乳头周围 CVI 显着降低 ( p < .001)，PEX 患者也显着降低与对照组相比值较低 ( p < .001)。与 PEX 组和对照组相比，PEG 组的颞部、鼻部、颞上、鼻上、颞下和鼻下部分的视盘周围 CVI 值显着降低 ( p < .001)。与对照组相比，PEX 组所有部门的视乳头周围 CVI 也较低（p< .001)。PEG 组的整体视盘周围脉络膜厚度明显薄于 PEX 组和对照组（分别为 133.37 ± 39.16、154.36 ± 33.28 和 157.82 ± 36.77 μm，p < .001）。

结论

在目前的研究中，表明 PEX 的存在导致 CVI 值下降，这种下降在 PEG 患者中最高。CVI 可能是显示 PEG 和 PEX 综合征中血管功能障碍的有用参数。