Omega-3 or n-3 polyunsaturated fatty acids (PUFAs) are widely studied for health benefits that may relate to anti-inflammatory activity. However, mechanisms mediating an anti-inflammatory response to n-3 PUFA intake are not fully understood. Of interest is the emerging role of fatty acids to impact DNA methylation (DNAm) and thereby modulate mediating inflammatory processes. In this pilot study, we investigated the impact of n-3 PUFA intake on DNAm in inflammation-related signaling pathways in peripheral blood mononuclear cells (PBMCs) of women at high risk of breast cancer.

中文翻译：

---

一项试点研究中膳食 omega-3 脂肪酸摄入量影响外周血 DNA 甲基化 - 抗炎作用和个体差异


Omega-3 或 n-3 多不饱和脂肪酸 (PUFA) 因其可能与抗炎活性相关的健康益处而被广泛研究。然而，介导 n-3 PUFA 摄入的抗炎反应的机制尚不完全清楚。令人感兴趣的是脂肪酸影响 DNA 甲基化 (DNAm) 从而调节介导炎症过程的新作用。在这项初步研究中，我们研究了 n-3 PUFA 摄入量对乳腺癌高危女性外周血单核细胞 (PBMC) 炎症相关信号通路 DNAm 的影响。