Polycaprolactone/hydroxyapatite (PCL/HA) composite coating was fabricated by a combination of hydrothermal and dipping methods to delay the degradation of Mg alloy AZ31 as bioresorbable materials. The PCL/HA coating was composed of nano rod-shape HA crystals and PCL filled in the space of HA crystals. Compared with the single HA coating, the binding strength between the PCL/HA composite coating and Mg alloy was obviously improved and the PCL/HA coating still adhered to the surface of AZ31 substrate even after 38 days of immersion. The electrochemical corrosion rate of HA coated sample was reduced by ten times after being filled by PCL. The electrochemical impedance spectroscopy (EIS) and immersion test results showed that the PCL/HA composite coating could provide a more effective barrier for Mg substrate than the HA coating alone. The cytocompatibility and the antibacterial property of HA coating and PCL/HA coating were evaluated by culturing with bone marrow-derived mesenchymal stem cells (BMSCs) and methicillin-resistant staphylococcus aureus (MRSA) for 24 h under direct culture conditions, respectively. The PCL/HA composite coating showed better BMSC cell compatibility, more suitable for BMSC adhesion than HA coating alone and showed a potential application prospect as a biological materials. However, from the perspective of clinical applications, the antibacterial property of PCL/HA composite coating needs to be further improved.

采用水热法和浸渍法相结合的方法制备聚己内酯/羟基磷灰石 (PCL/HA) 复合涂层，以延缓 AZ31 镁合金作为生物可吸收材料的降解。PCL/HA涂层由纳米棒状HA晶体和填充在HA晶体空间中的PCL组成。与单一HA涂层相比，PCL/HA复合涂层与镁合金的结合强度明显提高，浸泡38天后PCL/HA涂层仍能附着在AZ31基体表面。HA涂层样品在填充PCL后电化学腐蚀速率降低了10倍。电化学阻抗谱（EIS）和浸泡测试结果表明，PCL/HA复合涂层比单独的HA涂层可以为镁基体提供更有效的阻隔。通过与骨髓间充质干细胞 (BMSCs) 和耐甲氧西林金黄色葡萄球菌 (MRSA) 在直接培养条件下分别培养 24 h 来评估 HA 涂层和 PCL/HA 涂层的细胞相容性和抗菌性能。PCL/HA复合涂层表现出更好的BMSC细胞相容性，比单独的HA涂层更适合BMSC粘附，显示出作为生物材料的潜在应用前景。但从临床应用来看，PCL/HA复合涂层的抗菌性能有待进一步提高。