Colon adenocarcinoma (COAD) is a common malignant tumor of the digestive tract that threatens human health seriously. Thus, it is urgent to explore biomarkers that can be used to evaluate a patient's survival prognosis overall as a supplementary treatment. RNA-seq expression profiles were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus, and Lasso and multivariate Cox regression analyses were used for developing the prognostic model. Finally, a nomogram comprising the prognostic model was established to evaluate survival overall. A risk model comprised of a total of 12 immune-related gene pairs was constructed. Further analysis revealed the model's independent prognostic ability in relation to other clinical characteristics. This model's nomogram could help clinicians choose personalized treatment for COAD patients. This model has significant potential to complement COAD's clinical identifying characteristics, and also provide new insights into the identification of colon cancer patients with a high risk of death.

中文翻译：

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鉴定和验证 12 个免疫相关基因作为结肠腺癌的预后特征

结肠腺癌（COAD）是消化道常见的恶性肿瘤，严重威胁人类健康。因此，迫切需要探索可用于评估患者总体生存预后的生物标志物作为补充治疗。RNA-seq 表达谱从癌症基因组图谱和基因表达综合体下载，套索和多变量 Cox 回归分析用于开发预后模型。最后，建立包含预后模型的列线图以评估总体生存率。构建了由总共12个免疫相关基因对组成的风险模型。进一步的分析揭示了该模型相对于其他临床特征的独立预后能力。该模型的列线图可以帮助临床医生为 COAD 患者选择个性化治疗。