Abstract

Background

Behcet’s disease (BD) may present with life threating complications including neurological and cardiovascular involvement. Neuro-Behcet’s disease (NBD) is one of the most important causes of morbidity and mortality in patients with BD. The aim of the present study is to investigate whether patients with NBD are different than BD patients with other manifestations in terms of subclinical myocardial dysfunction.

Methods

Forty patients with NBD (23 female, mean age: 42.4 ± 9.4 years), 40 patients with BD (9 female, mean age: 39.7 ± 9.0 years) and 40 controls (20 male, mean age: 41.8 ± 6.5 years) were consecutively included in the study. All subjects underwent a transthoracic echocardiography for evaluation of left ventricular (LV) and atrial (LA) functions with two-dimensional (2D) speckle tracking echocardiography (STE).

Results

Baseline characteristics, clinical data, LV dimensions, systolic and diastolic functions were all in normal range among the groups. LV global longitudinal strain (LV-GLS) was significantly lower in patients with NBD and BD patients without neurologic involvement compared to controls. LA conduit strain was significantly lower in patients with NBD compared to controls. Patients with both parenchymal NBD and vascular NBD manifestations had significantly lower LV-GLS and LA conduit strain compared to controls. Linear regression analysis demonstrated that among cardiovascular risk factors only presence of NBD was the independent predictor of LV-GLS.

Conclusions

BD is associated with impaired LV and LA functions. LV-GLS and LA conduit strains of the patients with NBD were lower. NBD was an independent predictor of LV-GLS, suggesting a link between neurological manifestations and cardiac dysfunction in BD patients.

中文翻译：

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神经白塞病患者的白塞病心肌受累程度可能更高：斑点追踪超声心动图研究

摘要

背景

白塞病 (BD) 可能会出现危及生命的并发症，包括神经和心血管受累。神经白塞病 (NBD) 是导致 BD 患者发病和死亡的最重要原因之一。本研究的目的是调查 NBD 患者在亚临床心肌功能障碍方面是否与具有其他表现的 BD 患者不同。

方法

40 名 NBD 患者（23 名女性，平均年龄：42.4 ± 9.4 岁）、40 名 BD 患者（9 名女性，平均年龄：39.7 ± 9.0 岁）和 40 名对照者（20 名男性，平均年龄：41.8 ± 6.5 岁）连续接受纳入研究。所有受试者都接受了经胸超声心动图检查，以使用二维 (2D) 斑点追踪超声心动图 (STE) 评估左心室 (LV) 和心房 (LA) 功能。

结果

各组的基线特征、临床数据、左室大小、收缩和舒张功能均在正常范围内。与对照组相比，NBD 患者和没有神经系统受累的 BD 患者的 LV 整体纵向应变 (LV-GLS) 显着降低。与对照组相比，NBD 患者的 LA 导管应变显着降低。与对照组相比，具有实质性 NBD 和血管 NBD 表现的患者的 LV-GLS 和 LA 导管应变显着降低。线性回归分析表明，在心血管危险因素中，只有 NBD 的存在是 LV-GLS 的独立预测因子。

结论

BD 与 LV 和 LA 功能受损有关。NBD患者的LV-GLS和LA导管应变较低。NBD 是 LV-GLS 的独立预测因子，表明 BD 患者的神经系统表现与心脏功能障碍之间存在联系。