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Nephroprotective activity of Vetiveria zizanioides (L.) Nash supplement in doxorubicin-induced nephrotoxicity model of Wistar rats
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-08-16 , DOI: 10.1111/jfbc.13901 Sachinthi S Amarasiri 1 , Anoja P Attanayake 2 , Liyanagae D A M Arawwawala 3 , Kamani A P W Jayatilaka 2 , Lakmini K B Mudduwa 4
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-08-16 , DOI: 10.1111/jfbc.13901 Sachinthi S Amarasiri 1 , Anoja P Attanayake 2 , Liyanagae D A M Arawwawala 3 , Kamani A P W Jayatilaka 2 , Lakmini K B Mudduwa 4
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The nephroprotective effect of standardized aqueous root extract of Vetiveria zizanioides (L.) Nash (Family: Poaceae) was investigated in doxorubicin-induced (20 mg/kg, ip) experimental nephrotoxicity model of Wistar rats. The freeze-dried aqueous refluxed (4 hr) root extract of V. zizanioides (25, 50; equivalent human therapeutic dose and 100 mg/kg) was administered separately to nephrotoxic Wistar rats (n = 6/group). Supplement of V. zizanioides resulted a dose-dependent reduction in raised serum creatinine, β2-microglobulin, and blood urea nitrogen and a subsequent increase in serum total protein and albumin in nephrotoxic rats (p < .05). An attenuation of the doxorubicin-induced features of renal parenchymal injury was observed on H- and E-stained sections of the kidney tissues. Nootkatone, dehydroaromadendrene, isokhusenic acid, α-vetivone, and isolongifolene were identified in the methanol extract of V. zizanioides based on the GC-MS chromatogram analysis. The findings revealed that the supplement of standardized aqueous root extract of V. zizanioides had a significant dose-dependent nephroprotective activity against doxorubicin-induced experimental nephrotoxicity.
中文翻译：
Vetiveria zizanioides (L.) Nash 补充剂在阿霉素诱导的 Wistar 大鼠肾毒性模型中的肾保护活性
在Wistar 大鼠的多柔比星诱导 (20 mg/kg, ip) 实验肾毒性模型中研究了标准化的香根草(L.) Nash (家庭：禾本科)水根提取物的肾保护作用。V的冷冻干燥水回流（4 小时）根提取物。zizanioides (25, 50; 等效人类治疗剂量和 100 mg/kg) 分别给予肾毒性 Wistar 大鼠 ( n = 6/组)。的补充香根草导致升高血清肌酐的剂量依赖性降低，β 2 -微球蛋白，和血尿素氮和血清总蛋白，白蛋白在肾毒性大鼠（一个随后增加p < .05）。在肾组织的 H 和 E 染色切片上观察到阿霉素诱导的肾实质损伤特征减弱。诺卡酮，dehydroaromadendrene，isokhusenic酸，α-vetivone，和异长叶烯在的甲醇提取物进行鉴定香根草基于由GC-MS色谱分析。研究结果表明，补充标准化的V根水提取物。zizanioides对多柔比星诱导的实验性肾毒性具有显着的剂量依赖性肾保护活性。
更新日期：2021-09-06
中文翻译：
Vetiveria zizanioides (L.) Nash 补充剂在阿霉素诱导的 Wistar 大鼠肾毒性模型中的肾保护活性
在Wistar 大鼠的多柔比星诱导 (20 mg/kg, ip) 实验肾毒性模型中研究了标准化的香根草(L.) Nash (家庭：禾本科)水根提取物的肾保护作用。V的冷冻干燥水回流（4 小时）根提取物。zizanioides (25, 50; 等效人类治疗剂量和 100 mg/kg) 分别给予肾毒性 Wistar 大鼠 ( n = 6/组)。的补充香根草导致升高血清肌酐的剂量依赖性降低，β 2 -微球蛋白，和血尿素氮和血清总蛋白，白蛋白在肾毒性大鼠（一个随后增加p < .05）。在肾组织的 H 和 E 染色切片上观察到阿霉素诱导的肾实质损伤特征减弱。诺卡酮，dehydroaromadendrene，isokhusenic酸，α-vetivone，和异长叶烯在的甲醇提取物进行鉴定香根草基于由GC-MS色谱分析。研究结果表明，补充标准化的V根水提取物。zizanioides对多柔比星诱导的实验性肾毒性具有显着的剂量依赖性肾保护活性。
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