Cyanobacteria are attractive candidates for photoautotrophic production of platform chemicals due to their inherent ability to utilize carbon dioxide as the sole carbon source. Metabolic pathways can be engineered more readily in cyanobacteria compared to higher photosynthetic organisms. Although significant progress has been made in pathway engineering, intracellular accumulation of the product is a potential bottleneck in large-scale production. Likewise, substrate uptake is known to limit growth and product formation. These limitations can potentially be addressed by targeted and controlled expression of transporter proteins in the metabolically engineered strains. This review focuses on the transporters that have been explored in cyanobacteria. To highlight the progress on characterization and application of cyanobacterial transporters, we applied text analytics to extract relevant information from over 1000 publications. We have categorized the transporters based on their source, their function and the solute they transport. Further, the review provides insights into the potential of transporters in the metabolic engineering of cyanobacteria for improved product titer.

由于蓝藻具有利用二氧化碳作为唯一碳源的固有能力，因此蓝藻是平台化学品光合自养生产的有吸引力的候选者。与高等光合生物相比，蓝藻中的代谢途径更容易设计。尽管在通路工程方面取得了重大进展，但产物的细胞内积累是大规模生产的潜在瓶颈。同样，已知底物吸收会限制生长和产物形成。这些限制可以通过代谢工程菌株中转运蛋白的靶向和受控表达来解决。这篇综述的重点是已经在蓝藻中探索过的转运蛋白。为了突出蓝藻转运蛋白的表征和应用进展，我们应用文本分析从 1000 多份出版物中提取相关信息。我们根据转运蛋白的来源、功能和转运的溶质对转运蛋白进行了分类。此外，该综述提供了对转运蛋白在蓝藻代谢工程中提高产品滴度的潜力的见解。