Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model,Hypertension

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Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model
Hypertension ( IF 6.9 ) Pub Date : 2021-08-15 , DOI: 10.1161/hypertensionaha.121.17567
Rebekka Vogtmann ₁ , Jacqueline Heupel ₁ , Florian Herse _{2,

3} , Mahsa Matin ₄ , Henning Hagmann ₄ , Ivo Bendix ₅ , Kristin Kräker _{2,

3,

6} , Ralf Dechend _{2,

7} , Elke Winterhager ₈ , Rainer Kimmig ₁ , Angela Köninger _{1,

9} , Alexandra Gellhaus ₁

Affiliation

Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).
Experimental and Clinical Research Center (ECRC), a cooperation of Charité - Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany (F.H., K.K., R.D.).
Max Delbruck Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany (F.H., K.K.).
Department II of Internal Medicine-Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine-University Hospital Cologne, Cologne, Germany and Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases, Germany (M.M., H.H.).
Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University of Duisburg-Essen, Germany (I.B.).
Charité-Universitätsmedizin Berlin and Humboldt-Universität zu Berlin, Berlin, Germany (K.K.).
HELIOS Klinikum, Berlin, Germany (R.D.).
Imaging Center Essen, EM Unit, University Hospital Essen, Germany (E.W.).
Department of Gynecology and Obstetrics, Clinic of the Order of St. John, St. Hedwigs Clinic, Regensburg, Germany (A.K.).