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Use of feline herpesvirus as a vaccine vector offers alternative applications for feline health
Veterinary Microbiology ( IF 2.4 ) Pub Date : 2021-08-16 , DOI: 10.1016/j.vetmic.2021.109210
Ellen Cottingham 1 , Thurid Johnstone 2 , Carol A Hartley 1 , Joanne M Devlin 1
Affiliation  

Herpesviruses are attractive vaccine vector candidates due to their large double stranded DNA genome and latency characteristics. Within the scope of veterinary vaccines, herpesvirus-vectored vaccines have been well studied and commercially available vectored vaccines are used to help prevent diseases in different animal species. Felid alphaherpesvirus 1 (FHV-1) has been characterised as a vector candidate to protect against a range of feline pathogens. In this review we highlight the methods used to construct FHV-1 based vaccines and their outcomes, while also proposing alternative uses for FHV-1 as a viral vector.



中文翻译:

使用猫疱疹病毒作为疫苗载体为猫的健康提供了替代应用

疱疹病毒是有吸引力的候选疫苗载体,因为它们具有较大的双链 DNA 基因组和潜伏期特征。在兽用疫苗范围内,疱疹病毒载体疫苗已得到充分研究,商业上可获得的载体疫苗用于帮助预防不同动物物种的疾病。猫科动物 α 疱疹病毒 1 (FHV-1) 已被定性为一种候选载体,可抵御一系列猫科病原体。在这篇综述中,我们重点介绍了用于构建基于 FHV-1 的疫苗的方法及其结果,同时还提出了 FHV-1 作为病毒载体的替代用途。

更新日期:2021-08-19
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