Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions,European Journal of Immunology

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Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions
European Journal of Immunology ( IF 4.5 ) Pub Date : 2021-08-16 , DOI: 10.1002/eji.202048909
Oyebola O Oyesola ₁ , Elia D Tait Wojno ₁

Affiliation

Type 2 immunity is critical for the protective and repair responses that mediate resistance to parasitic helminth infection. This immune response also drives aberrant inflammation during atopic diseases. Prostaglandins are a class of critical lipid mediators that are released during type 2 inflammation and are integral in controlling the initiation, activation, maintenance, effector functions, and resolution of Type 2 inflammation. In this review, we explore the roles of the different prostaglandin family members and the receptors they bind to during allergen- and helminth-induced Type 2 inflammation and the mechanism through which prostaglandins promote or suppress Type 2 inflammation. Furthermore, we discuss the potential role of prostaglandins produced by helminth parasites in the regulation of host–pathogen interactions, and how prostaglandins may regulate the inverse relationship between helminth infection and allergy. Finally, we discuss opportunities to capitalize on our understanding of prostaglandin pathways to develop new therapeutic options for humans experiencing Type 2 inflammatory disorders that have a significant prostaglandin-driven component including allergic rhinitis and asthma.

中文翻译：

2 型炎症的前列腺素调节：从基础生物学到治疗干预

2 型免疫对于介导对寄生虫感染的抵抗力的保护和修复反应至关重要。这种免疫反应还会在特应性疾病期间引发异常炎症。前列腺素是一类在 2 型炎症期间释放的关键脂质介质，在控制 2 型炎症的起始、激活、维持、效应器功能和消退中是不可或缺的。在这篇综述中，我们探讨了不同前列腺素家族成员及其结合的受体在过敏原和蠕虫诱导的 2 型炎症过程中的作用，以及前列腺素促进或抑制 2 型炎症的机制。此外，我们讨论了蠕虫寄生虫产生的前列腺素在调节宿主 - 病原体相互作用中的潜在作用，以及前列腺素如何调节蠕虫感染和过敏之间的反比关系。最后，我们讨论了利用我们对前列腺素途径的理解为患有 2 型炎症性疾病的人类开发新的治疗选择的机会，这些疾病具有重要的前列腺素驱动成分，包括过敏性鼻炎和哮喘。

更新日期：2021-10-06

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