Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.

行为和神经生理学的日常节律是所有动物生物钟不可或缺的一部分。人脑中生物钟调节的例子包括睡眠-觉醒的日常节律、认知功能、嗅觉敏感性和缺血性中风的风险，所有这些都与许多 COVID-19 患者表现出的症状重叠。受昼夜节律功能与 COVID-19 神经系统症状之间相对未探索但普遍存在的重叠的启发，这篇透视作品使用嗅觉的日常变化以及睡眠和清醒时间作为说明性示例。我们建议时间戳临床数据和测试可以扩展和完善 COVID-19 的诊断和治疗。