Calcitonin gene-related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain,CNS Neuroscience & Therapeutics

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Calcitonin gene-related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-08-16 , DOI: 10.1111/cns.13720
Chenyan Sun ₁ , Qi An ₁ , Ruidi Li ₁ , Shuhui Chen ₁ , Xinpei Gu ₁ , Shuhong An ₁ , Zhaojin Wang ₁

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Calcitonin gene-related peptide (CGRP) as a regulator of astrocyte activation may facilitate spinal nociceptive processing. Histone H3 lysine 9 acetylation (H3K9ac) is considered an important regulator of cytokine and chemokine gene expression after peripheral nerve injury. In this study, we explored the relationship between CGRP and H3K9ac in the activation of astrocytes, and elucidated the underlying mechanisms in the pathogenesis of chronic neuropathic pain.

中文翻译：

降钙素基因相关肽诱导星形胶质细胞组蛋白 H3 赖氨酸 9 乙酰化与神经性疼痛大鼠神经炎症相关

降钙素基因相关肽 (CGRP) 作为星形胶质细胞活化的调节剂可能促进脊髓伤害性处理。组蛋白 H3 赖氨酸 9 乙酰化 (H3K9ac) 被认为是周围神经损伤后细胞因子和趋化因子基因表达的重要调节因子。在这项研究中，我们探讨了 CGRP 和 H3K9ac 在星形胶质细胞活化中的关系，并阐明了慢性神经性疼痛发病机制的潜在机制。

更新日期：2021-10-11

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