In this research work, the effect of tungsten (W) doping on the crystal structure, morphology and anticancer activity of titanium dioxide (TiO₂) nanoparticles were studied. The synthesized W doped TiO₂ nanoparticles have been characterized by spectroscopic and microscopic techniques. XRD pattern of pure TiO₂ and 1 wt% W-doped TiO₂ nanoparticles confirms the anatase structure and increase in the W-doping changes the phase of TiO₂ to rutile. The images of HRTEM clearly confirm that size of 5 wt% W-doped TiO₂ nanoparticles are in the range of ~ 40 nm. The FESEM images show the agglomerated spherical-like morphology for pure TiO₂, 1 wt%, 3 wt% W-doped TiO₂ nanoparticles and flower like morphology for 5 wt% W-doped TiO₂ nanoparticles. Both pure TiO₂ and W-doped TiO₂ nanoparticles did not show any notable cytotoxicity against human normal embryonic kidney cell line (HEK 293), but showed effective cytotoxicity against HeLa cancer cell lines evaluated by MTT assay.

在这项研究工作中，研究了钨 (W) 掺杂对二氧化钛 (TiO ₂ ) 纳米粒子的晶体结构、形貌和抗癌活性的影响。合成的 W 掺杂的 TiO ₂纳米粒子已通过光谱和显微技术表征。纯 TiO ₂和 1 wt% W 掺杂的 TiO ₂纳米颗粒的XRD 图案证实了锐钛矿结构，W 掺杂的增加将 TiO ₂的相变为金红石。HRTEM 的图像清楚地证实了 5 wt% W 掺杂的 TiO ₂纳米颗粒的尺寸在 ~ 40 nm 的范围内。FESEM 图像显示了纯 TiO ₂ , 1 wt%, 3 wt% W 掺杂的 TiO的团聚球状形态₂纳米颗粒和 5 wt% W 掺杂的 TiO ₂纳米颗粒的花状形态。纯 TiO ₂和 W 掺杂的 TiO ₂纳米颗粒对人正常胚胎肾细胞系 (HEK 293) 均未显示出任何显着的细胞毒性，但对通过 MTT 测定评估的 HeLa 癌细胞系显示出有效的细胞毒性。