Three New 2,2′-Difurylketone Derivatives and Two New Chromones from the Rehmanniae Radix Praeparata,Chemistry & Biodiversity

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Three New 2,2′-Difurylketone Derivatives and Two New Chromones from the Rehmanniae Radix Praeparata
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-08-16 , DOI: 10.1002/cbdv.202100237
Jingke Zhang _{1,

2} , Jinjin Lyu _{1,

2} , Shengchao Wang _{1,

2} , Meng Li _{1,

2} , Juanjuan Liu _{1,

2} , Denghui Zhu _{1,

2} , Jingya Shi _{1,

2} , Junjun Wie _{1,

2} , Xiaoke Zheng _{1,

2} , Weisheng Feng _{1,

2}

Affiliation

Rehmanniae Radix Praeparata is the processed products of the root of Rehmannia glutinosa. It has been used as a Traditional Chinese Medicine for thousands of years, and it has been found to possess widely pharmacological activities. In this study, three new 2,2′-difurylketone derivatives (rehmanniaeketone A–C) and two new chromones [3,8-dihydroxy-2-(2-hydroxyethyl)chromone and 3,8-dihydroxy-2-[(2-O-α-D-galactopyranosyloxy)ethyl]chromone] were isolated from the Rehmanniae Radix Praeparata. Furthermore all of the compounds were subjected to cytotoxic testing against the human lung carcinoma A549 cells. The cytotoxic results showed that rehmanniaeketone B and rehmanniaeketone C exhibited more stronger inhibition effects on the cell activity of A549 cells with the IC₅₀ 5.23 μM and 2.05 μM than other compounds. And 3,8-dihydroxy-2-(2-hydroxyethyl)chromone exhibited moderately inhibitory activity with the IC₅₀ 61 μM. Rehmanniaeketone A and 3,8-dihydroxy-2-[(2-O-α-D-galactopyranosyloxy]chromone showed no inhibitory effects.

中文翻译：

来自熟地黄的三个新的 2,2'-二呋喃酮衍生物和两个新的色酮

熟地黄是熟地黄根的加工品。它作为中药使用已有数千年历史，并已被发现具有广泛的药理活性。在这项研究中，三种新的 2,2'-二呋喃酮衍生物（熟地黄酮 A-C）和两种新的色酮 [3,8-二羟基-2-（2-羟乙基）色酮和 3,8-二羟基-2-[(2 - O - α-D-吡喃半乳糖氧基)乙基]色酮]从熟地黄中分离。此外，所有化合物都进行了针对人肺癌 A549 细胞的细胞毒性测试。细胞毒性结果表明，地黄酮B和地黄酮C对A549细胞的细胞活性具有更强的抑制作用，IC ₅₀ 5.23 μM和2.05 μM比其他化合物更强。3,8-二羟基-2-(2-羟乙基)色酮表现出中等抑制活性，IC ₅₀ 61 μM。Rehmanniaeketone A 和 3,8-dihydroxy-2-[(2- O - α -D-galactopyranosyloxy]chromone 没有显示出抑制作用。

更新日期：2021-10-19

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