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Breath-by-breath analysis of respiratory sinus arrhythmia in dogs
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-08-15 , DOI: 10.1016/j.resp.2021.103776
Giovanni Grosso 1 , Tommaso Vezzosi 1 , Angela Briganti 1 , Chiara Di Franco 1 , Rosalba Tognetti 1 , Jacopo P Mortola 2
Affiliation  

Dogs differ greatly in size, heart (HR) and breathing rates (BR). In addition, they have a clear Respiratory Sinus Arrhythmia (RSA) at rest. Therefore, better than any other mammalian species, dogs offer an opportunity to test whether resting RSA varies with body weight, HR or BR. Sequences of inter-beat-intervals (IBI, ms) a few-minutes long were collected in twenty-three resting dogs of different sizes, together with pneumograms. IBI variability was quantified by standard time-domain criteria. From beat-to-beat instantaneous heart rate (hR, beats/min), RSA was the difference between inspiratory peak (hR-peak) and expiratory trough (hR-trough), in percent of mean HR. RSA averaged 40.1 % ±4.5, or more than three times that of humans, with large inter-animal variability. On average, RSA contributed 38 % of the total IBI variability. RSA did not differ between sexes and did not correlate with body weight. It had modest negative correlations with HR (P < 0.05) and BR (P < 0.05), and a very strong negative correlation with hR-trough (P < 0.001). In two separate dogs, during panting, RSA was absent. In the transition from resting to panting, RSA continued like at rest for several breaths, despite the tachypnea, underlying the importance of central mechanisms in the origin of RSA. In conclusion, RSA in dogs is very large and explains less than half of their sinus arrhythmia. Rather than HR, BR or hR-peak, changes in the vago-sympathetic control, represented by hR-trough, are the most likely source of variability of RSA among subjects.



中文翻译:

犬呼吸性窦性心律失常的逐次呼吸分析

狗的体型、心脏 (HR) 和呼吸频率 (BR) 差异很大。此外,他们在休息时有明显的呼吸性窦性心律失常 (RSA)。因此,与任何其他哺乳动物相比,狗提供了一个测试静息 RSA 是否随体重、HR 或 BR 变化的机会。在 23 只不同大小的休息犬中收集了几分钟长的节拍间隔 (IBI, ms) 序列以及肺动脉造影。IBI 变异性通过标准时域标准进行量化。从每搏瞬时心率(hR,beats/min 来看,RSA是吸气峰(h R-peak)和呼气谷(hR-谷),以平均 HR 的百分比表示。RSA 平均为 40.1 % ±4.5,是人类的三倍多,动物间变异性很大。平均而言,RSA 贡献了总 IBI 变异性的 38%。RSA在性别之间没有差异,并且与体重无关。它与 HR (P < 0.05) 和 BR (P < 0.05) 呈适度的负相关,与hR-谷值呈非常强的负相关 (P < 0.001)。在两只不同的狗中,在喘气期间,RSA 不存在。在从休息到喘气的过渡过程中,尽管呼吸急促,RSA 仍像休息时一样持续数次呼吸,这表明中枢机制在 RSA 起源中的重要性。总之,狗的 RSA 非常大,并且解释了不到一半的窦性心律失常。而不是 HR、BR 或hR 峰,迷走神经交感神经控制的变化,由h R 谷代表,是受试者中 RSA 变异的最可能来源。

更新日期:2021-08-20
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