Abstract

A new modified chitosan derivative (N-acetyl,N’-chitosanacetohydrazide, ACsAH) and its cobalt(II), nickel(II), manganese(II), and copper(II) complexes were successfully prepared. Their structures were proven using elemental analysis, FTIR, ¹H-NMR and electronic spectroscopy, magnetic moment, and molar conductance. An octahedral stereochemistry for all the synthesized ACsAH–metal complexes was proposed. Their activity against the tested microbes can be arranged as follows: ACsAH–Mn(II) complex > ACsAH–Co(II) complex > ACsAH–Ni(II) complex > ACsAH–Cu(II) complex > ACsAH > chitosan. The ACsAH–Mn(II) complex exhibited a greater potency in inhibition of the growth of some of the tested microbes than that of the used standard drugs.

摘要

成功制备了一种新型改性壳聚糖衍生物（N-乙酰，N'-壳聚糖乙酰肼，ACsAH）及其钴（II）、镍（II）、锰（II）和铜（II）配合物。^{使用元素分析、FTIR、 1} H-NMR 和电子光谱、磁矩和摩尔电导证明了它们的结构。提出了所有合成的 ACsAH-金属配合物的八面体立体化学。它们对被测微生物的活性排列如下：ACsAH-Mn(II) 配合物 > ACsAH-Co(II) 配合物 > ACsAH-Ni(II) 配合物 > ACsAH-Cu(II) 配合物 > ACsAH > 壳聚糖。ACsAH-Mn(II) 复合物在抑制某些测试微生物的生长方面表现出比使用的标准药物更强的效力。