Abstract

In the present study, to advance the skin tissue regeneration process, aspirin (AS)-loaded polycaprolactone (PCL) and maltodextrin (MD) composite nanofiber was prepared via electrospinning technique. The results showed that the composite had more uniform nanofibers and the mean diameter of the nanofibers was reduced from 186 to 96 nm experimentally with increasing AS percentages. Biological evaluations proved that L929 fibroblast cells on the PCL/MD with 2% AS had better cell adhesion and proliferation. The overall results introduce that 2% AS incorporated in the PCL/MD electrospun nanofibers can be applied as a promising candidate for further studies toward skin tissue regeneration.

摘要

在本研究中，为了促进皮肤组织再生过程，通过静电纺丝技术制备了负载阿司匹林 (AS) 的聚己内酯 (PCL) 和麦芽糊精 (MD) 复合纳米纤维。结果表明，复合材料具有更均匀的纳米纤维，并且随着 AS 百分比的增加，纳米纤维的平均直径从 186 nm 减小到 96 nm。生物学评价证明，2% AS 的 PCL/MD 上的 L929 成纤维细胞具有更好的细胞粘附和增殖能力。总体结果表明，在 PCL/MD 电纺纳米纤维中掺入 2% AS 可作为进一步研究皮肤组织再生的有希望的候选者。