Abstract

In the current study, via using the mixed-ligand synthesis approach, two new Co(II)-based coordination polymers (CPs), [Co(1,4-PDA)(L)(H₂O)]_n (1) and [Co(5-AIP)(L)(H₂O)]_n (2) and (L = 1,3-bis(5,6-dimethylbenzimidazol-1-yl)propane, 5-H₂AIP = 5-aminoisophthalic acid, 1,4-H₂PDA = 1,4-phenylenediacetic acid) were hydrothermally synthesized and structurally characterized. The as-prepared two coordination polymers have been studied via the single crystal X-ray diffraction study along with the elemental analysis. Their application values on the coronary artery heart disease (CHD) was evaluated and the related mechanism was discussed as well. Firstly, the ELISA (enzyme linked immunosorbent assay) detection assay was performed to measure the levels of the inflammatory cytokines released into the plasma. Then, the relative expression of the NF-κb signaling pathway was determined by the real time RT-PCR (reverse transcription-polymerase chain reaction) after the compound treatment. Above all, compound 1 showed much better application values than compound 2 on coronary artery heart disease by inhibiting NF-κb signaling pathway activation.

摘要

在目前的研究中，通过使用混合配体合成方法，两种新的 Co(II) 基配位聚合物 (CPs)，[Co(1,4-PDA)(L)(H ₂ O)] _n ( 1 ) [Co(5-AIP)(L)(H ₂ O)] _n ( 2 )和(L = 1,3-双(5,6-二甲基苯并咪唑-1-基)丙烷，5-H ₂ AIP = 5 -氨基间苯二甲酸，1,4-H ₂PDA = 1,4-苯二乙酸）是水热合成和结构表征的。通过单晶 X 射线衍射研究和元素分析研究了所制备的两种配位聚合物。评价了它们在冠心病（CHD）中的应用价值，并讨论了相关机制。首先，进行ELISA（酶联免疫吸附测定）检测测定以测量释放到血浆中的炎性细胞因子的水平。然后，在化合物处理后，通过实时RT-PCR（逆转录-聚合酶链反应）测定NF-κb信号通路的相对表达。最重要的是，化合物1显示出比化合物2更好的应用价值 通过抑制 NF-κb 信号通路激活对冠心病的作用。