The present paper provides the first integrated assessment of the capacity of luteolin to induce hormetic dose responses. It was shown that luteolin induced hormetic responses in multiple biological systems, including enhancing neuroprotection in various experimental model disease systems, improving wounding healing, especially in experimental models of high-risk population subgroups, such as diabetics, as well as enhancing osteogenesis in models of osteoporosis. The mechanistic basis for the luteolin-induced hormetic dose responses has been demonstrated to commonly involve the upregulation of the nuclear factor erythroid-derived 2-like 2 (Nrf2), which mediates the extensive range of anti-inflammatory effects induced by luteolin in multiple cell types and organ systems.

本文首次对木犀草素诱导兴奋剂量反应的能力进行综合评估。结果表明，木犀草素在多个生物系统中诱导兴奋反应，包括增强各种实验模型疾病系统中的神经保护，改善伤口愈合，特别是在高危人群亚组（如糖尿病患者）的实验模型中，以及增强骨形成模型中的成骨作用。骨质疏松症。木犀草素诱导的兴奋剂量反应的机制基础已被证明通常涉及核因子红细胞衍生的 2 样 2 (Nrf2) 的上调，其介导木犀草素在多细胞中诱导的广泛抗炎作用类型和器官系统。