The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants as ROS neutralizer comes from flavonoid that contain in propolis. Most researchers claim that flavonoid can be used to protect the liver. The aim of this study was to test the hepatoprotective effect of flavonoid in propolis from South Sulawesi against doxorubicin and epirubicin. The experiment included male Sprague dawley rats divided into nine groups. The rats received the microcapsule propolis or the quercetin orally for 15 days. The hepatotoxicity was promoted by injection epirubicin and doxorubicin (i.v.) with a cumulative dose of 9 mg/kg. In this study, total polyphenol and flavonoid tests of propolis have been carried out, there were 1.1% polyphenols and 2.7% flavonoids, the antioxidant activity tests showed IC50 value of 9849 ppm and LCMS/MS tests supported the presence of phenolic compounds in propolis from South Sulawesi. Liver parameter was measured and the results showed that the propolis 200 mg/kg group produced the lowest ALT and had potential protective effect against doxorubicin and epirubicin-induced hepatotoxicity.

使用阿霉素和表柔比星作为化疗药物会引起副作用，例如由于活性氧 (ROS) 的氧化应激导致肝损伤，导致作为肝脏参数的 ALT 和 AST 水平升高。作为 ROS 中和剂的天然抗氧化剂的一种来源来自蜂胶中含有的类黄酮。大多数研究人员声称黄酮类化合物可用于保护肝脏。本研究的目的是测试来自南苏拉威西岛的蜂胶中的黄酮类化合物对阿霉素和表柔比星的保肝作用。该实验包括分为九组的雄性 Sprague Dawley 大鼠。大鼠口服蜂胶微胶囊或槲皮素 15 天。注射表柔比星和多柔比星 (iv) 的累积剂量为 9 mg/kg，可促进肝毒性。在这项研究中，进行了蜂胶的总多酚和黄酮类化合物测试，多酚含量为 1.1%，黄酮类化合物含量为 2.7%，抗氧化活性测试显示 IC50 值为 9849 ppm，LCMS/MS 测试支持南苏拉威西蜂胶中存在酚类化合物。测量肝脏参数，结果表明蜂胶 200 mg/kg 组产生的 ALT 最低，并且对多柔比星和表柔比星引起的肝毒性具有潜在的保护作用。