Glioma is a common tumor in the human central nervous system. However, its molecular mechanism in the pathogenesis and regulation of glioma progression is still unclear. In this study, we found that GLIS3 was up-regulated in glioma tissues, and the increased expression is positively correlated with advanced tumor grade. Survival evaluation disclosed that patients with high expression levels of GLIS3 normally have a poor prognosis. Functional analysis revealed the oncogenic role of GLIS3 in the development of glioma. GLIS3 promotes glioma cells’ invasion, migration, and proliferation. Meanwhile, deficiency of GLIS3 produces an inhibitory function upon NF-κB signaling pathway. This work demonstrated that GLIS3, acting as a target and prognostic factor for glioma, may promote the invasion, migration and proliferation of glioma cells involved in regulation of NF-κB signaling pathway.

神经胶质瘤是人类中枢神经系统的常见肿瘤。然而，其在胶质瘤进展的发病机制和调控中的分子机制仍不清楚。在这项研究中，我们发现 GLIS3 在胶质瘤组织中上调，并且表达增加与晚期肿瘤分级呈正相关。生存评估揭示了具有高表达水平的 GLIS3 的患者通常预后不良。功能分析揭示了 GLIS3 在胶质瘤发展中的致癌作用。GLIS3 促进胶质瘤细胞的侵袭、迁移和增殖。同时，GLIS3缺乏对NF-κB信号通路产生抑制作用。这项工作表明，作为胶质瘤的靶点和预后因素的 GLIS3 可能会促进侵袭，