Prostate cancer is one of the most common cancers in the world, and its early detection is vital to saving the lives of patients. In this research, a novel label-free photoelectrochemical immunosensor was designed for sensitive detection of prostate specific antigen (PSA). Ag₂S sensitized on Ag/AgBr/BiOBr heterojunction could effectively inhibit photogenic holes recombination and improve photocurrent response and sensitivity. Ascorbic acid was an effective electron donor, which can effectively eliminate photo-generated holes. The photocurrent reduced linearly with the logarithm of PSA concentration ranged from 0.001 to 50 ng·mL⁻¹ and the limit of detection was 0.25 pg·mL⁻¹. The designed sensor had the advantages of wide linear range, good stability, high reproducibility, and good selectivity. This study not only provided a method for efficient and sensitive detection of PSA, but also provided valuable reference ideas for the detection of other tumor markers.

前列腺癌是世界上最常见的癌症之一，其早期发现对于挽救患者的生命至关重要。在这项研究中，设计了一种新型无标记光电化学免疫传感器，用于灵敏检测前列腺特异性抗原 (PSA)。在Ag/AgBr/BiOBr异质结上敏化的Ag ₂ S可以有效抑制光生空穴复合，提高光电流响应和灵敏度。抗坏血酸是一种有效的电子供体，可以有效地消除光生空穴。^{光电流在0.001～50 ng·mL -1}范围内随PSA浓度的对数呈线性下降，检出限为0.25 pg·mL ^-1. 所设计的传感器具有线性范围宽、稳定性好、重现性好、选择性好等优点。本研究不仅为高效灵敏地检测PSA提供了方法，也为其他肿瘤标志物的检测提供了有价值的参考思路。