当前位置: X-MOL 学术Hepatob. Pancreat. Dis. Int. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Comparison and development of advanced machine learning tools to predict nonalcoholic fatty liver disease: An extended study
Hepatobiliary & Pancreatic Diseases International ( IF 3.6 ) Pub Date : 2021-08-14 , DOI: 10.1016/j.hbpd.2021.08.004
Yuan-Xing Liu 1 , Xi Liu 1 , Chao Cen 1 , Xin Li 2 , Ji-Min Liu 3 , Zhao-Yan Ming 4 , Song-Feng Yu 1 , Xiao-Feng Tang 1 , Lin Zhou 1 , Jun Yu 1 , Ke-Jie Huang 2 , Shu-Sen Zheng 1
Affiliation  

Background

Nonalcoholic fatty liver disease (NAFLD) is a public health challenge and significant cause of morbidity and mortality worldwide. Early identification is crucial for disease intervention. We recently proposed a nomogram-based NAFLD prediction model from a large population cohort. We aimed to explore machine learning tools in predicting NAFLD.

Methods

A retrospective cross-sectional study was performed on 15 315 Chinese subjects (10 373 training and 4942 testing sets). Selected clinical and biochemical factors were evaluated by different types of machine learning algorithms to develop and validate seven predictive models. Nine evaluation indicators including area under the receiver operating characteristic curve (AUROC), area under the precision-recall curve (AUPRC), accuracy, positive predictive value, sensitivity, F1 score, Matthews correlation coefficient (MCC), specificity and negative prognostic value were applied to compare the performance among the models. The selected clinical and biochemical factors were ranked according to the importance in prediction ability.

Results

Totally 4018/10 373 (38.74%) and 1860/4942 (37.64%) subjects had ultrasound-proven NAFLD in the training and testing sets, respectively. Seven machine learning based models were developed and demonstrated good performance in predicting NAFLD. Among these models, the XGBoost model revealed the highest AUROC (0.873), AUPRC (0.810), accuracy (0.795), positive predictive value (0.806), F1 score (0.695), MCC (0.557), specificity (0.909), demonstrating the best prediction ability among the built models. Body mass index was the most valuable indicator to predict NAFLD according to the feature ranking scores.

Conclusions

The XGBoost model has the best overall prediction ability for diagnosing NAFLD. The novel machine learning tools provide considerable beneficial potential in NAFLD screening.

更新日期:2021-10-09
down
wechat
bug