Objective

Numerous epidemiological studies have been published to elucidate the potential associations of IL-17A -197G/A (rs2275913) and IL-17F 7488T/C (rs763780) with cancer risk in Asians. Nevertheless, the results from different studies remain controversial. To identify the roles of the two polymorphisms in cancer risk, we performed this current meta-analysis.

Methods

The available literature was derived from five databases, covering relevant articles updated through February 17, 2021. Five different analysis models with corresponding odds ratios (ORs) and 95% confidence intervals (CIs) were applied to appraise the gene-disease correlation.

Results

In total, 43 case-control studies with 31237 subjects were enrolled. Overall analyses indicated that there was significantly increased cancer risk led by IL-17A -197G/A under the five analysis models. A similar tendency was also identified in the subgroup analysis of cancer type, especially for gastric cancer, cervical cancer, colorectal cancer, and oral carcinoma. As for IL-17F 7488T/C, we revealed that patients who carried this variant had a higher cancer risk in the recessive model among the overall analyses, as well as subgroup analyses of cervical cancer or oral carcinoma.

Conclusions

In summary, our work confirmed that IL-17A -197G/A acted as a risk factor for diverse cancer types and that IL-17F 7488T/C might be involved in cervical cancer and oral carcinoma.

中文翻译：

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IL-17A -197G/A 和 IL-17F 7488T/C 多态性与亚洲人癌症风险的关联：来自 43 项研究的最新荟萃分析

客观的

许多流行病学研究已经发表，以阐明 IL-17A -197G/A (rs2275913) 和 IL-17F 7488T/C (rs763780) 与亚洲人癌症风险的潜在关联。尽管如此，不同研究的结果仍然存在争议。为了确定这两种多态性在癌症风险中的作用，我们进行了当前的荟萃分析。

方法

现有文献来自五个数据库，涵盖更新至 2021 年 2 月 17 日的相关文章。 应用具有相应优势比 (OR) 和 95% 置信区间 (CI) 的五种不同分析模型来评估基因与疾病的相关性。

结果

总共纳入了 43 项病例对照研究，涉及 31237 名受试者。总体分析表明，在五种分析模型下，IL-17A -197G/A 导致癌症风险显着增加。在癌症类型的亚组分析中也发现了类似的趋势，尤其是胃癌、宫颈癌、结直肠癌和口腔癌。至于 IL-17F 7488T/C，我们发现在整体分析以及宫颈癌或口腔癌的亚组分析中，携带该变异的患者在隐性模型中具有更高的癌症风险。

结论

总之，我们的工作证实 IL-17A -197G/A 是多种癌症类型的危险因素，并且 IL-17F 7488T/C 可能与宫颈癌和口腔癌有关。