Abstract

A novel ligand, tetra-azamacrocyclic, L(C₂₄H₁₆N₁₂O₂S₄) and its complexes with the structures, [MLCl₂] and [CuL]Cl₂ (where M = Ni(II), Fe(II); L = S,S′-[benzene-1,3-diylbis(4H-1,2,4-triazole-5,3-diyl)]bis{[(5-benzene-1,3-diyl-4H-1,2,4-triazol-3yl)sulfanyl] ethanethioate} were described and depicted by the analytical and spectral techniques. These studies revealed an octahedral geometry for Ni(II) and Fe(II) structures, while the Cu(II) complex exhibited a square planar structure. All the integrated metal structures were screened against targeted species of pathogenic fungi and bacterial strains to evaluate in vitro antimicrobial activities. The binding capability of the complexes with CT-DNA was considered by supporting detailed examination followed by viscosity measurements and thermal denaturation studies. The mode of DNA cleavage using gel electrophoreses revealed that the complexes possess photonuclease characteristics against pUC19 DNA under UV–visible irradiation. The newly synthesized novel Cu(II)-L complex has been proven to be a potential DNA cleavage agent and a potent inhibitor against both the bacterial and fungi strains.

Introduction

中文翻译：

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具有药理意义的四氮杂大环金属配合物受三唑约束的 DNA 特异性链断裂研究进展及体外生物学评价评价

摘要

一种新型配体，四氮杂大环，L(C ₂₄ H ₁₆ N ₁₂ O ₂ S ₄ ) 及其与结构 [MLCl ₂ ] 和 [CuL]Cl _{2 的}配合物（其中 M = Ni(II), Fe(II) ); L =  S,S' -[benzo-1,3-diylbis(4H-1,2,4-triazole-5,3-diyl)]bis{[(5-benzo-1,3-diyl-4H) -1,2,4-三唑-3基）硫烷基]乙硫醇}被分析和光谱技术描述和描绘。这些研究揭示了Ni（II）和Fe（II）结构的八面体几何形状，而Cu（II）复合物呈方形平面结构，所有的金属结构都针对病原真菌和细菌菌株的目标物种进行筛选，以进行体外评估抗菌活性。复合物与 CT-DNA 的结合能力是通过支持详细检查，然后是粘度测量和热变性研究来考虑的。使用凝胶电泳的 DNA 切割模式表明，在紫外-可见光照射下，复合物具有针对 pUC19 DNA 的光核酸酶特性。新合成的新型 Cu(II)-L 复合物已被证明是一种潜在的 DNA 切割剂和一种针对细菌和真菌菌株的有效抑制剂。

介绍