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A versatile system for neuromuscular stimulation and recording in the mouse model using a lightweight magnetically coupled headmount
Journal of Neuroscience Methods ( IF 2.7 ) Pub Date : 2021-08-13 , DOI: 10.1016/j.jneumeth.2021.109319
Annie Vahedipour 1 , Matthew R Short 2 , Azadeh Timnak 3 , Omid Haji Maghsoudi 4 , Thomas Hallowell 5 , Jonathan Gerstenhaber 6 , Ornella Cappellari 7 , Michel Lemay 6 , Andrew J Spence 6
Affiliation  

Neural stimulation and recording in rodents are common methods to better understand the nervous system and improve the quality of life of individuals who are suffering from neurological disorders (e.g., epilepsy), as well as for permanent reduction of chronic pain in patients with neuropathic pain and spinal-cord injury. This method requires a neural interface (e.g., a headmount) to couple the implanted neural device with instrumentation system. The size and the total weight of such headmounts should be designed in a way to minimize its effect on the movement of the animal. This is a crucial factor in gait, kinematic, and behavioral neuroscience studies of freely moving mice. Here we introduce a lightweight ‘snap-in’ electro-magnetic headmount that is extremely small, and uses strong neodymium magnetics to enable a reliable connection without sacrificing the lightweight of the device. Additionally, the headmount requires minimal surgical intervention during the implantation, resulting in minimal tissue damage. The device has demonstrated itself to be robust, and successfully provided direct electrical stimulation of nerve and electrical muscle stimulation and recording, as well as powering implanted LEDs for optogenetic use scenarios.



中文翻译:

使用轻型磁耦合头戴式装置在小鼠模型中进行神经肌肉刺激和记录的多功能系统

啮齿动物的神经刺激和记录是更好地了解神经系统和改善患有神经系统疾病(例如癫痫)的个体的生活质量以及永久减少神经性疼痛患者的慢性疼痛的常用方法和脊髓损伤。该方法需要神经接口(例如,头戴式装置)来将植入的神经装置与仪器系统耦合。这种头架的尺寸和总重量的设计方式应尽量减少其对动物运动的影响。这是自由移动小鼠的步态、运动学和行为神经科学研究的关键因素。在这里,我们介绍了一种轻巧的“卡入式”电磁头戴式耳机,它非常小,并使用强大的钕磁体来实现可靠的连接,而不会牺牲设备的重量。此外,头戴式支架在植入过程中需要最少的手术干预,从而使组织损伤最小。该设备已证明其坚固耐用,并成功提供了神经和电肌肉刺激和记录的直接电刺激,以及为光遗传学使用场景的植入 LED 供电。

更新日期:2021-08-19
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