In recent years considerable progress has been made in identifying the impact of mRNA translation in tumour progression. Cancer cells hijack the pre-existing translation machinery to thrive under the adverse conditions originating from intrinsic oncogenic programs, that increase their energetic demand, and from the hostile microenvironment. A key translation program frequently dysregulated in cancer is the Integrated Stress Response, that reprograms translation by attenuating global protein synthesis to decrease metabolic demand while increasing translation of specific mRNAs that support survival, migration, immune escape. In this review we provide an overview of the Integrated Stress Response, emphasise its dual role during tumorigenesis and cancer progression, and highlight the therapeutic strategies available to target it.

近年来，在确定 mRNA 翻译对肿瘤进展的影响方面已经取得了相当大的进展。癌细胞劫持预先存在的翻译机制，在源自内在致癌程序的不利条件下茁壮成长，这些不利条件增加了它们的能量需求，并且来自敌对的微环境。癌症中经常失调的一个关键翻译程序是综合应激反应，它通过减弱整体蛋白质合成来重新编程翻译，以减少代谢需求，同时增加支持生存、迁移和免疫逃逸的特定 mRNA 的翻译。在这篇综述中，我们概述了综合应激反应，强调其在肿瘤发生和癌症进展过程中的双重作用，并强调了可用于靶向它的治疗策略。