Background: Apoptosis plays an essential role in the development and treatment of tumors, and caspase-8 (CASP8) plays an important role in the enzyme cascade reaction that leads to apoptosis. Human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer is highly aggressive and has a high recurrence rate and poor prognosis. This study investigated whether lentivirus-mediated Gag-CASP8 can effectively deliver activated CASP8 into primary human breast cancer cells overexpressing HER-2 to induce apoptosis and explore the underlying mechanism.

中文翻译：

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慢病毒介导的 Gag-Caspase-8 对 HER-2 过表达原代人乳腺癌细胞生长的抑制作用

背景：细胞凋亡在肿瘤的发生发展和治疗中起着至关重要的作用，而caspase-8（ CASP8）在导致细胞凋亡的酶级联反应中起重要作用。人表皮生长因子受体 2 (HER-2) 过表达乳腺癌具有高度侵袭性，复发率高，预后差。本研究调查了慢病毒介导的 Gag-CASP8 是否可以有效地将活化的 CASP8 递送到过表达 HER-2 的原代人乳腺癌细胞中以诱导细胞凋亡并探索其潜在机制。