Ageing is an inevitable process of physical deterioration that impairs functional autonomy and quality of life, becoming a public health issue.

Since the percentage of people over 60 years is increasing worldwide, the use of easily detectable biomarkers of ageing is a relevant tool for monitoring of the ageing process and treatment. Among them, Klotho, an ageing suppressor gene because its deficiency leads to ageing like phenotype, seems particularly promising.

This systematic review includes the last 10 years clinical studies that evaluated the association between plasma Klotho and body composition, physical performance and frailty in both sedentary and active middle-aged and older adults.

Sixteen studies have been found: nine regarding the association between Klotho and body composition, two the association of Klotho and frailty and finally five concerning the effects of physical activity on Klotho.

The results of these studies, albeit with some exceptions, point out that Klotho is positively associated with muscle strength and negatively with osteoporosis, frailty, disability and mortality while physical activity generally increases Klotho levels.

Moreover, even if there are still few clinical studies, Klotho might be positively associated with bone mineral density, muscle strength, longevity, mobility and robustness during ageing.

衰老是身体退化的必然过程，会损害功能自主性和生活质量，成为一个公共卫生问题。

由于全球 60 岁以上人口的比例在不断增加，因此使用易于检测的衰老生物标志物是监测衰老过程和治疗的相关工具。其中，Klotho，一种衰老抑制基因，因为它的缺乏导致类似表型的衰老，似乎特别有前途。

该系统评价包括最近 10 年的临床研究，这些研究评估了久坐不动和活跃的中老年人的血浆 Klotho 与身体成分、身体机能和虚弱之间的关联。

已发现 16 项研究：九项关于 Klotho 与身体成分之间的关​​联，两项关于 Klotho 与虚弱的关联，最后五项关于体育活动对 Klotho 的影响。

尽管有一些例外，这些研究的结果指出，Klotho 与肌肉力量呈正相关，与骨质疏松症、虚弱、残疾和死亡率呈负相关，而体育活动通常会增加 Klotho 水平。

此外，即使临床研究仍然很少，但 Klotho 可能与衰老过程中的骨矿物质密度、肌肉力量、寿命、活动性和健壮性呈正相关。