In recent years, personalized cancer vaccines have gained increasing attention as emerging immunotherapies with the capability to overcome interindividual differences and show great benefits for individual patients in the clinic due to the highly tailored vaccine formulations. A large number of materials have been studied as delivery vectors to enhance the therapeutic performance of personalized cancer vaccines, including artificial materials, engineered microorganisms, cells and cell derivatives. These delivery vectors with distinct features are employed to change antigen biodistributions and to facilitate antigen uptake, processing and presentation, improving the strength, velocity, and duration of the immune response when delivered by different strategies. Here, we provide an overview of personalized cancer vaccine delivery vectors, describing their materials, physicochemical properties, delivery strategies and challenges for clinical transformation.

近年来，个性化癌症疫苗作为新兴的免疫疗法受到越来越多的关注，由于高度定制的疫苗配方，它能够克服个体间的差异，并在临床上对个体患者显示出巨大的益处。已经研究了大量的材料作为递送载体，以提高个性化癌症疫苗的治疗性能，包括人工材料、工程微生物、细胞和细胞衍生物。这些具有不同特征的递送载体用于改变抗原生物分布，促进抗原摄取、加工和呈递，提高通过不同策略递送时免疫反应的强度、速度和持续时间。在这里，我们概述了个性化癌症疫苗递送载体，