Differently to most chemically synthesized medical materials, polyhydroxyalkanoates (PHAs) are intracellular carbon and energy storage granules, which is a family of natural bio-polymers synthesized by microorganism's materials. Due to excellent biocompatibility reasonable biodegradability and versatile material difference, PHAs are well medical biomaterials candidates for applications in tissue engineering and drug delivery, including commercial PHB, PHBV, PHBHHx, PHBVHHx, P34HB and few uncommercial PHAs. Electrospinning nanofibers with the size of 10–10,000 nm can improve the mechanical properties and decrease the crystallinity of PHA, meanwhile simulate the structure and function of native extracellular matrix of cells. Hence, PHAs electrospinning nanofibers as engineered scaffolds have been widely used for tissue engineering scaffolds in cardiovascular, vascular, nerve, bone, cartilage and skin; also, as carriers for application in drug delivery system. In this review, we highlight the extraction and properties of medical PHAs from natural or engineered microorganism, and microstructure, current manufacturing techniques and medical applications of electrospinning nanofibers of PHAs. Moreover, the current challenges and prospects of PHAs electrospinning nanofibers are discussed rationally, providing an insight into developing vibrant fields of PHAs electrospinning nanofibers-based biomedicine.

中文翻译：

---

微生物聚羟基链烷酸酯的静电纺丝纳米纤维在医学组织工程中的应用

与大多数化学合成的医用材料不同，聚羟基链烷酸酯（PHA）是细胞内碳和储能颗粒，是由微生物材料合成的天然生物聚合物家族。由于优异的生物相容性、合理的生物降解性和通用的材料差异，PHA 是组织工程和药物递送应用的良好医学生物材料候选者，包括商业 PHB、PHBV、PHBHHx、PHBVHHx、P34HB 和少数非商业 PHA。静电纺丝尺寸为10-10,000 nm的纳米纤维可以改善PHA的力学性能并降低其结晶度，同时模拟细胞天然细胞外基质的结构和功能。因此，PHAs静电纺丝纳米纤维作为工程支架已广泛应用于心血管、血管、神经、骨骼、软骨和皮肤的组织工程支架；也可作为载体应用于给药系统。在这篇综述中，我们重点介绍了从天然或工程微生物中提取医用 PHA 的特性，以及静电纺丝 PHA 纳米纤维的微观结构、当前制造技术和医学应用。此外，还理性地讨论了 PHAs 静电纺纳米纤维的当前挑战和前景，为发展 PHAs 静电纺纳米纤维生物医学的充满活力的领域提供了见解。我们重点介绍了从天然或工程微生物中提取医用 PHA 的性质和性质，以及静电纺丝 PHA 纳米纤维的微观结构、当前制造技术和医学应用。此外，还理性地讨论了 PHAs 静电纺纳米纤维的当前挑战和前景，为发展 PHAs 静电纺纳米纤维生物医学的充满活力的领域提供了见解。我们重点介绍了从天然或工程微生物中提取医用 PHA 的性质和性质，以及静电纺丝 PHA 纳米纤维的微观结构、当前制造技术和医学应用。此外，还理性地讨论了 PHAs 静电纺纳米纤维的当前挑战和前景，为发展 PHAs 静电纺纳米纤维生物医学的充满活力的领域提供了见解。