Metastasis is a key factor that affects the prognosis of colorectal cancer (CRC), and patients with metastasis have limited treatment options and poor prognoses. EGF, latrophilin, and seven transmembrane domains containing 1 (ELTD1/ADGRL4) are members of the adhesion G protein-coupled receptor (aGPCR) superfamily. In this study, high expression of ELTD1 was correlated with lymph node metastasis and poor outcomes in CRC patients. Both in vitro and in vivo studies showed that ELTD1 markedly promoted the invasion and metastasis of CRC. Moreover, ELTD1 accelerated the transcriptional activity of MMP2, which could rescue the impaired invasiveness of CRC cells caused by the downregulation of ELTD1 expression. In conclusion, our study suggests that ELTD1 might be a potential novel target for the treatment of CRC metastasis.

中文翻译：

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ELTD1通过激活结直肠癌中的MMP2促进侵袭和转移

转移是影响结直肠癌（CRC）预后的关键因素，转移患者的治疗选择有限，预后较差。EGF、latrophilin 和包含 1 个 (ELTD1/ADGRL4) 的七个跨膜结构域是粘附 G 蛋白偶联受体 (aGPCR) 超家族的成员。在本研究中，ELTD1 的高表达与 CRC 患者的淋巴结转移和不良预后相关。体外和体内研究均表明ELTD1显着促进CRC的侵袭和转移。此外，ELTD1 加速了 MMP2 的转录活性，这可以挽救由 ELTD1 表达下调引起的 CRC 细胞侵袭性受损。总之，我们的研究表明 ELTD1 可能是治疗 CRC 转移的潜在新靶点。