Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets.

中文翻译：

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盘子上的蘑菇：NAFLD 治疗、健康改善和可持续饮食的趋势

非酒精性脂肪性肝病 (NAFLD) 是肝病的最重要原因。与其他非传染性疾病 (NCD) 类似，例如肥胖症和 II 型糖尿病，NAFLD 会受到饮食的强烈影响。与饮食相关的非传染性疾病和营养不良在所有地区都在上升，成为全球健康、经济和环境负担的主要原因。蘑菇是自狩猎采集社区以来的重要饮食成分，由于它们在新陈代谢特征中的相互作用，在生物医学研究和治疗中越来越获得动力。我们在此强调富含蘑菇的饮食对脂质和糖代谢稳态的有益影响，包括它们的调节作用，但也会干扰胰岛素代谢、肠道微生物群、炎症、氧化应激和自噬。在本次审查中，